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Research Grade Dupilumab ( 度匹魯單抗 )
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產品名稱:

Research Grade Dupilumab ( 度匹魯單抗 )

NO.
011
貨號:
CSD00304
中文名稱
度匹魯單抗
英文名詞
Research Grade Dupilumab
CAS號
1190264-60-8
產品貨號:
CSD00304
貨期:
現貨
價格與訂購:
2480.00
數量
-
+
庫存:
100
沒有此類產品
產品信息
如何訂購
貨號(Catalog No.)icon
CSD00304
通用名INNicon
Dupilumab
純度(Purity)icon
>95%
濃度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
內毒素(Endotoxin level)icon
Please contact with the lab for this information.
產品描述(Description)icon
Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.
別名(Alternative names)icon
CD124,REGN668,SAR231893
靶點;物種(Specificity target name;species)icon
IL4R/CD124[Homo sapiens]
活性研究(體外/體內研究)(Activity in vitro)icon
Dupilumab suppressed mRNA expressions of genes related to activation of T cells, DCs, eosinophils, inflammatory pathways, and TH2-inducing chemokines in skin lesions. No significant reduction in IL-17A or IL-22 levels is detected, but large reductions in expression of IL-17–related genes, such as elafin (PI3), IL23p19/IL23A, and S100A8 and trends for suppression (CXCL1 and S100A7) are found with 300 mg of Dupilumab.
Major suppressions of hyperplasia-related genes (eg, K16) and reductions in expression of S100A genes are evident with 300 mg of Dupilumab by using microarrays and qRT-PCR. The changes in other critical epidermal alterations in severe atopic dermatitis (AD) skin are also measured, including significant increases in claudin and lipid product levels with 300 mg of Dupilumab. A trend of dose-dependent increases in expression of differentiation genes (LOR and FLG) is observed after adjusting for suppression of epidermal hyperplasia, as demonstrated by K16 reductions with Dupilumab.
種類(Species)icon
Homo sapiens
受體鑒定(Receptor identification)icon
IgG4-kappa
CASicon
1190264-60-8
存儲條件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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