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Research Grade Sarilumab
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產品名稱:

Research Grade Sarilumab

NO.
009
貨號:
CSD00271
中文名稱
Research Grade Sarilumab
英文名詞
Research Grade Sarilumab
CAS號
1189541-98-7
產品貨號:
CSD00271
貨期:
現貨
價格與訂購:
2480.00
數量
-
+
庫存:
100
沒有此類產品
產品信息
如何訂購
貨號(Catalog No.)icon
CSD00271
通用名INNicon
Sarilumab
純度(Purityicon
>95%
濃度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
內毒素(Endotoxin level)icon
Please contact with the lab for this information.
產品描述(Description)icon
Sarilumab is a fully human anti-IL-6R monoclonal IgG1 antibody that binds to both membrane bound and soluble interleukin 6 (IL-6) receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6 1. Sarilumab was developped by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approved in May 2017 and followed by EU approval in June 2017 for the treatment of moderate to severe Rheumatoid Arthritis (RA) in combination with methotrexate 4. RA is a chronic inflammatory disease characterized by polyarthritis and its treatment has been challenged by the different response in every patient 3. Subcutaneous administration of Sarilumab has been shown to decrease acute-phase reactant levels and improve in clinical RA symptoms 2.
別名(Alternative names)icon
REGN88,SAR153191
靶點;物種(Specificity target name;species)icon
EGFR/ERBB1 [Homo sapiens]
種類(Species)icon
Homo sapiens
受體鑒定(Receptor identification)icon
IgG1-kappa
分子量(MV)icon
150000.0 Da (143900 Da in absence of N-glycosylation in heavy chains (Asn296) )
CASicon
1189541-98-7
存儲條件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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