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Research Grade Necitumumab ( 奈妥木單抗 )
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產品名稱:

Research Grade Necitumumab ( 奈妥木單抗 )

NO.
003
貨號:
CSD00193
中文名稱
奈妥木單抗
英文名詞
Research Grade Necitumumab
CAS號
906805-06-9
產品貨號:
CSD00193
貨期:
現貨
價格與訂購:
2480.00
數量
-
+
庫存:
100
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產品信息
如何訂購
貨號(Catalog No.)icon
CSD00193
通用名INNicon
Necitumumab
純度(Purityicon
>95%
濃度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
內毒素(Endotoxin level)icon
Please contact with the lab for this information.
產品描述(Description)icon
Necitumumab is an intravenously administered recombinant monoclonal IgG1 antibody used in the treatment of non-small cell lung cancer (NSCLC) as an EGFR antagonist. It functions by binding to epidermal growth factor receptor (EGFR) and prevents binding of its ligands, a process that is involved in cell proliferation, metastasis, angiogenesis, and malignant progression. Binding of necitumumab to EGFR induces receptor internalization and degradation, thereby preventing further activation of EGFR which is beneficial in NSCLC as many patients have increased protein expression of EGFR. Necitumumab is approved for use in combination with cisplatin and gemcitabine as a first-line treatment for metastatic squamous non-small cell lung cancer (NSCLC).
別名(Alternative names)icon
11F8,IMC-11F8,LY3012211
靶點;物種(Specificity target name;species)icon
EGFR/ERBB1 [Homo sapiens]
種類(Species)icon
Homo sapiens
受體鑒定(Receptor identification)icon
IgG1-kappa
CASicon
906805-06-9
存儲條件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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